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Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine

Received: 21 November 2014     Accepted: 24 November 2014     Published: 27 December 2014
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Abstract

From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.

Published in Journal of Plant Sciences (Volume 3, Issue 1-2)

This article belongs to the Special Issue Ethnopharmacological Investigation of Medicinal Plants

DOI 10.11648/j.jps.s.2015030102.18
Page(s) 40-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Ethnomedicine, Securinane-Type Alkaloids, Antimicrobial, Antiprotozoal

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Cite This Article
  • APA Style

    Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. (2014). Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. Journal of Plant Sciences, 3(1-2), 40-46. https://doi.org/10.11648/j.jps.s.2015030102.18

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    ACS Style

    Diallo M. S. T.; Baldé M. A.; Camara A.; Traoré M. S.; Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J. Plant Sci. 2014, 3(1-2), 40-46. doi: 10.11648/j.jps.s.2015030102.18

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    AMA Style

    Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J Plant Sci. 2014;3(1-2):40-46. doi: 10.11648/j.jps.s.2015030102.18

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  • @article{10.11648/j.jps.s.2015030102.18,
      author = {Diallo M. S. T. and Baldé M. A. and Camara A. and Traoré M. S. and Bah M. L. and Diallo A. S. and Camara A. K. and Laurent S. and Roch A. and Muller R. N. and Maes L. and Pieters L. and Baldé A. M.},
      title = {Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine},
      journal = {Journal of Plant Sciences},
      volume = {3},
      number = {1-2},
      pages = {40-46},
      doi = {10.11648/j.jps.s.2015030102.18},
      url = {https://doi.org/10.11648/j.jps.s.2015030102.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2015030102.18},
      abstract = {From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine
    AU  - Diallo M. S. T.
    AU  - Baldé M. A.
    AU  - Camara A.
    AU  - Traoré M. S.
    AU  - Bah M. L.
    AU  - Diallo A. S.
    AU  - Camara A. K.
    AU  - Laurent S.
    AU  - Roch A.
    AU  - Muller R. N.
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    AU  - Pieters L.
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    N1  - https://doi.org/10.11648/j.jps.s.2015030102.18
    DO  - 10.11648/j.jps.s.2015030102.18
    T2  - Journal of Plant Sciences
    JF  - Journal of Plant Sciences
    JO  - Journal of Plant Sciences
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    PB  - Science Publishing Group
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    AB  - From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.
    VL  - 3
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Author Information
  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

  • Département de Pharmacie, Faculté de Médecine-Pharmacie-Odontostomatologie, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée

  • Service de Chimie Générale, Organique et Biomédicale

  • Service de Chimie Générale, Organique et Biomédicale

  • Service de Chimie Générale, Organique et Biomédicale

  • Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium

  • Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium

  • Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée

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