| Peer-Reviewed

Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes

Received: 31 October 2014     Accepted: 4 November 2014     Published: 27 December 2014
Views:       Downloads:
Abstract

The use of phytomedicine to treat many chronic diseases as diabetes is current in developing countries and pharmacological data in some case support this use. The aim of this study is to evaluate the efficacy and safety of Englerina lecardii leaves in the treatment of type 2 diabetes. An open label study design was designed to examine the effects of leave of Englerina lecardii at a dose of 15g/day in three divided doses during 90 days in 31 subjects with type 2 diabetes. 25 patients (9 men and 16 women ; age ) completed the study. On average, glycaemia at the end of treatment was decreased by 80 mg/dl (+-xx). Only mild and temporary side effects were observed, without leading to interrupt the treatment. In conclusion, the use of Englerina lecardii showed significant hypoglycemic effect without any major side effect. These data need to be confirm in a standard double blinded clinical trial.

Published in Journal of Plant Sciences (Volume 3, Issue 1-2)

This article belongs to the Special Issue Ethnopharmacological Investigation of Medicinal Plants

DOI 10.11648/j.jps.s.2015030102.15
Page(s) 24-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Englerina lecardii, Loranthaceae, Type 2 Diabetes, Efficacy, Safety

References
[1] Wallace TM, Matthews DR. Poor glycaemic control in type 2 diabetes: a conspiracy of disease, suboptimal therapy and attitude. QJM. 2000;93(6):369-74.
[2] Malviya N., Jain S. and Malviya S (2010): Antidiabetic potential of medicinal plants. Acta Poloniae Pharmaceutica - Drug Research, 67, 2; 113-118
[3] Gul-e-Rana, Karim S, Khurhsid R, Saeed-ul-Hassan S, Tariq I, Sultana M, et al. Hypoglycemic activity of Ficus racemosa bark in combination with oral hypoglycemic drug in diabetic human. Acta Pol Pharm. 2013; 70(6):1045-9.
[4] Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani B. The clinical investigation of citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trial. Phytotherapy Research. 2009; 23(8):1186-9.
[5] Noor A, Bansal VS, Vijayalakshmi MA. Current update on anti-diabetic biomolecules from key traditional Indian medicinal plants. Current science. 2013; 104(6):721-7.
[6] Jia W, Gao W, Tang L. Antidiabetic herbal drugs officially approved in China. Phytotherapy Research. 2003; 17(10): 1127-34.
[7] Hung H-Y, Qian K, Morris-Natschke SL, Hsu C-S, Lee K-H. Recent discovery of plant-derived anti-diabetic natural products. Natural Product Reports. 2012; 29(5):580-606.
[8] Ezuruike UF, Prieto JM. The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations. J Ethnopharmacol. 2014;155(2): 857-924.
[9] Keter LK, Mutiso PC. Ethnobotanical studies of medicinal plants used by Traditional Health Practitioners in the management of diabetes in Lower Eastern Province, Kenya. Journal of Ethnopharmacology. 2012;139(1):74-80.
[10] Vandebroek I. Intercultural health and ethnobotany: How to improve healthcare for underserved and minority communities? Journal of Ethnopharmacology. 2013;148(3):746-54.
[11] Baldé NM, Youla A, Baldé MD, Kaké A, Diallo MM, Baldé MA, et al. Herbal medicine and treatment of diabetes in Africa: an example from Guinea. Diabetes Metab. 2006;32(2):171-5.
[12] Diallo A, Traore MS, Keita SM, Balde MA, Keita A, Camara M, et al. Management of diabetes in Guinean traditional medicine: an ethnobotanical investigation in the coastal lowlands. J Ethnopharmacol. 2012;144(2):353-61.
[13] Prabhakar P.K., Doble M. (2009): Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 16; 1119-1126.
[14] Jung M, Park M, Lee HC, Kang YH, Kang ES, Kim SK. (2006): Antidiabetic agents from medicinal plants. Curr Med Chem.13, 10; 1203-18.
[15] Marles R. J. and Farnsworth N. R. (1995): Antidiabetic plants and their constituents. Phytomedicine 2 ; 2, 137-189
[16] Krentz AJ, Bailey CJ. Oral Antidiabetic Agents: Current Role in Type 2 Diabetes Mellitus. Drugs. 2005; 65(3): 385-411.
[17] Granberry MC, Fonseca VA. Cardiovascular Risk Factors Associated with Insulin Resistance: Effects of Oral Antidiabetic Agents. American Journal of Cardiovascular Drugs. 2005; 5(3):201-9.
[18] American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 2013 January; 36:S11-S66
[19] Coquet R. (2011): 250 examens de laboratoire. Prescriptions et interprétations. 11èEd. Maçon-Paris Cedex. 384p.
[20] Patel D.K, Prasad S.K, Kumar R., and Hemalatha S. (2012): An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed.; 2, 4; 320–330.
Cite This Article
  • APA Style

    E. S. Balde, N. M. Balde, M. S. Traore, M. A. Diallo, I. V. Camara, et al. (2014). Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes. Journal of Plant Sciences, 3(1-2), 24-27. https://doi.org/10.11648/j.jps.s.2015030102.15

    Copy | Download

    ACS Style

    E. S. Balde; N. M. Balde; M. S. Traore; M. A. Diallo; I. V. Camara, et al. Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes. J. Plant Sci. 2014, 3(1-2), 24-27. doi: 10.11648/j.jps.s.2015030102.15

    Copy | Download

    AMA Style

    E. S. Balde, N. M. Balde, M. S. Traore, M. A. Diallo, I. V. Camara, et al. Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes. J Plant Sci. 2014;3(1-2):24-27. doi: 10.11648/j.jps.s.2015030102.15

    Copy | Download

  • @article{10.11648/j.jps.s.2015030102.15,
      author = {E. S. Balde and N. M. Balde and M. S. Traore and M. A. Diallo and I. V. Camara and M. S. T. Diallo and M. A. Balde and A. Camara and A. M. Balde},
      title = {Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes},
      journal = {Journal of Plant Sciences},
      volume = {3},
      number = {1-2},
      pages = {24-27},
      doi = {10.11648/j.jps.s.2015030102.15},
      url = {https://doi.org/10.11648/j.jps.s.2015030102.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2015030102.15},
      abstract = {The use of phytomedicine to treat many chronic diseases as diabetes is current in developing countries and pharmacological data in some case support this use. The aim of this study is to evaluate the efficacy and safety of Englerina lecardii leaves in the treatment of type 2 diabetes. An open label study design was designed to examine the effects of leave of Englerina lecardii at a dose of 15g/day in three divided doses during 90 days in 31 subjects with type 2 diabetes. 25 patients (9 men and 16 women ; age ) completed the study. On average, glycaemia at the end of treatment was decreased by 80 mg/dl (+-xx). Only mild and temporary side effects were observed, without leading to interrupt the treatment. In conclusion, the use of Englerina lecardii showed significant hypoglycemic effect without any major side effect.  These data need to be confirm in a standard double blinded clinical trial.},
     year = {2014}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes
    AU  - E. S. Balde
    AU  - N. M. Balde
    AU  - M. S. Traore
    AU  - M. A. Diallo
    AU  - I. V. Camara
    AU  - M. S. T. Diallo
    AU  - M. A. Balde
    AU  - A. Camara
    AU  - A. M. Balde
    Y1  - 2014/12/27
    PY  - 2014
    N1  - https://doi.org/10.11648/j.jps.s.2015030102.15
    DO  - 10.11648/j.jps.s.2015030102.15
    T2  - Journal of Plant Sciences
    JF  - Journal of Plant Sciences
    JO  - Journal of Plant Sciences
    SP  - 24
    EP  - 27
    PB  - Science Publishing Group
    SN  - 2331-0731
    UR  - https://doi.org/10.11648/j.jps.s.2015030102.15
    AB  - The use of phytomedicine to treat many chronic diseases as diabetes is current in developing countries and pharmacological data in some case support this use. The aim of this study is to evaluate the efficacy and safety of Englerina lecardii leaves in the treatment of type 2 diabetes. An open label study design was designed to examine the effects of leave of Englerina lecardii at a dose of 15g/day in three divided doses during 90 days in 31 subjects with type 2 diabetes. 25 patients (9 men and 16 women ; age ) completed the study. On average, glycaemia at the end of treatment was decreased by 80 mg/dl (+-xx). Only mild and temporary side effects were observed, without leading to interrupt the treatment. In conclusion, the use of Englerina lecardii showed significant hypoglycemic effect without any major side effect.  These data need to be confirm in a standard double blinded clinical trial.
    VL  - 3
    IS  - 1-2
    ER  - 

    Copy | Download

Author Information
  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Service d’Endocrinologie, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Service d’Endocrinologie, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée

  • Service d’Endocrinologie, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Centre de Recherche et de Valorisation des Plantes Médicinales, Dubréka, Guinée

  • Sections