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Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis

Received: 19 November 2014     Accepted: 22 November 2014     Published: 27 December 2014
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Abstract

Objective: Association studies on the effects of GGCX gene polymorphisms on warfarin stable dose have shown conflicting results. The aim of this study is to quantitatively summarize whether GGCX gene polymorphisms have potential roles in warfarin dose requirement. Methods: Publications were searched in PubMed, Medline and ISI Web of Knowledge and chosen by exact inclusion and exclusion criteria. A meta-analysis was conducted by using Revman 5.0 software to determine the association between common polymorphisms of the three genes and warfarin dose requirement. Results: Data were extracted from 13 publications with 4167 patients enrolled. Two common polymorphisms (rs699664, rs12714145) of GGCX were included for further meta-analyses. Comparing to rs699664AA geontype carriers, rs699664GG genotype carriers requered higer 3% [95% CI: 2% - 4%, P-valus < 0.0001] warfarin dose. The warfarin dosage requirement showed no significant difference between rs699664GG and rs699664GA genotype carriers, P=0.51. Compared to rs12714145AA carriers, the GG and GA genotype carriers needed 5% (95% CI, 1% - 9%; P = 0.01) and 4% (95% CI, 1% - 8%; P = 0.02) lower warfarin dosage, respectively. The warfarin dosage requirement showed no significant difference between GG and GA genotype carriers, P=0.12. Conclusion: Our study showed that GGCX polymorphisms were significantly associated with warfarin dose requirement. These polymorphisms should be considered in future warfarin personalized treatment.

Published in American Journal of Life Sciences (Volume 3, Issue 1-4)

This article belongs to the Special Issue Pharmacogenomics & Personalized Medicine

DOI 10.11648/j.ajls.s.2015030104.12
Page(s) 7-13
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

GGCX, Warfarin, Polymorphism, Meta-Analysis

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Cite This Article
  • APA Style

    Zhiying Luo, Xi Li, Mouze Liu, Yan Shu, Jiye Yin, et al. (2014). Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis. American Journal of Life Sciences, 3(1-4), 7-13. https://doi.org/10.11648/j.ajls.s.2015030104.12

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    ACS Style

    Zhiying Luo; Xi Li; Mouze Liu; Yan Shu; Jiye Yin, et al. Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis. Am. J. Life Sci. 2014, 3(1-4), 7-13. doi: 10.11648/j.ajls.s.2015030104.12

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    AMA Style

    Zhiying Luo, Xi Li, Mouze Liu, Yan Shu, Jiye Yin, et al. Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis. Am J Life Sci. 2014;3(1-4):7-13. doi: 10.11648/j.ajls.s.2015030104.12

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  • @article{10.11648/j.ajls.s.2015030104.12,
      author = {Zhiying Luo and Xi Li and Mouze Liu and Yan Shu and Jiye Yin and Xiaoping Chen and Jianquan Luo and Xiaobing Li and Wei Zhang},
      title = {Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1-4},
      pages = {7-13},
      doi = {10.11648/j.ajls.s.2015030104.12},
      url = {https://doi.org/10.11648/j.ajls.s.2015030104.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2015030104.12},
      abstract = {Objective: Association studies on the effects of GGCX gene polymorphisms on warfarin stable dose have shown conflicting results. The aim of this study is to quantitatively summarize whether GGCX gene polymorphisms have potential roles in warfarin dose requirement. Methods: Publications were searched in PubMed, Medline and ISI Web of Knowledge and chosen by exact inclusion and exclusion criteria. A meta-analysis was conducted by using Revman 5.0 software to determine the association between common polymorphisms of the three genes and warfarin dose requirement. Results: Data were extracted from 13 publications with 4167 patients enrolled. Two common polymorphisms (rs699664, rs12714145) of GGCX were included for further meta-analyses. Comparing to rs699664AA geontype carriers, rs699664GG genotype carriers requered higer 3% [95% CI: 2% - 4%, P-valus < 0.0001] warfarin dose. The warfarin dosage requirement showed no significant difference between rs699664GG and rs699664GA genotype carriers, P=0.51. Compared to rs12714145AA carriers, the GG and GA genotype carriers needed 5% (95% CI, 1% - 9%; P = 0.01) and 4% (95% CI, 1% - 8%; P = 0.02) lower warfarin dosage, respectively. The warfarin dosage requirement showed no significant difference between GG and GA genotype carriers, P=0.12. Conclusion: Our study showed that GGCX polymorphisms were significantly associated with warfarin dose requirement. These polymorphisms should be considered in future warfarin personalized treatment.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis
    AU  - Zhiying Luo
    AU  - Xi Li
    AU  - Mouze Liu
    AU  - Yan Shu
    AU  - Jiye Yin
    AU  - Xiaoping Chen
    AU  - Jianquan Luo
    AU  - Xiaobing Li
    AU  - Wei Zhang
    Y1  - 2014/12/27
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajls.s.2015030104.12
    DO  - 10.11648/j.ajls.s.2015030104.12
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 7
    EP  - 13
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.s.2015030104.12
    AB  - Objective: Association studies on the effects of GGCX gene polymorphisms on warfarin stable dose have shown conflicting results. The aim of this study is to quantitatively summarize whether GGCX gene polymorphisms have potential roles in warfarin dose requirement. Methods: Publications were searched in PubMed, Medline and ISI Web of Knowledge and chosen by exact inclusion and exclusion criteria. A meta-analysis was conducted by using Revman 5.0 software to determine the association between common polymorphisms of the three genes and warfarin dose requirement. Results: Data were extracted from 13 publications with 4167 patients enrolled. Two common polymorphisms (rs699664, rs12714145) of GGCX were included for further meta-analyses. Comparing to rs699664AA geontype carriers, rs699664GG genotype carriers requered higer 3% [95% CI: 2% - 4%, P-valus < 0.0001] warfarin dose. The warfarin dosage requirement showed no significant difference between rs699664GG and rs699664GA genotype carriers, P=0.51. Compared to rs12714145AA carriers, the GG and GA genotype carriers needed 5% (95% CI, 1% - 9%; P = 0.01) and 4% (95% CI, 1% - 8%; P = 0.02) lower warfarin dosage, respectively. The warfarin dosage requirement showed no significant difference between GG and GA genotype carriers, P=0.12. Conclusion: Our study showed that GGCX polymorphisms were significantly associated with warfarin dose requirement. These polymorphisms should be considered in future warfarin personalized treatment.
    VL  - 3
    IS  - 1-4
    ER  - 

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Author Information
  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

  • Department of Cardio-Thoracic Surgery, the Second Xiangya Hospital Hospital of Central South University, Middle Ren-Min Road No. 139, Changsha, Hunan 410011, PR China

  • Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China

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